Selective electrochemical sensing of dopamine via solid-state hydrothermal β-cyclodextrin-functionalized selenium quantum dots-embedded with multiwall carbon nanotubes

초록

The selective electrochemical sensor was developed based on the surface functionalized selenium quantum dots (SeQDs) by (3-cyclodextrin ((3-CD) and boronic acid moieties and their incorporation into the multiwall carbon nanotubes (MWCNTs) on the GCE and SPE electrodes. The prepared (3-CD-SeQDs-APBA-MWCNTs nanocomposite-modified electrodes were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques for dopamine (DA) sensing. The SeQDs were synthesized using the solid-state hydrothermal approach without using solvent and demonstrated the average particle size of 6 nm. Initially, (3-CD-modified SeQDs ((3-CD-SeQDs) and then APBA (i.e., (3-CD-SeQDs-APBA), and finally, this (3-CD-SeQDs-APBA was functionalized with MWCNTs through non-covalent interactions. To the best of our knowledge, the novel (3-CDSeQDs-APBA- MWCNTs sensor was selectively detected DA in both GCE and SPE electrodes with the linear concentration ranges of 0-1000 nM and 0-5 mu M in the PBS buffer using both CV and DPV techniques, respectively. These (3-CD-SeQDs-APBA-MWCNTs nanocomposite was selectively applied for DA sensing and achieved desired detection limits over both GCE; 70.9 nM and 113.38 nM and SPE; 0.76 mu M and 0.82 mu M electrodes in the PBS buffer via CV and DPV techniques, respectively. In addition, nanocomposite showed high stability, reproducibility, and improved selectivity. The practicality of the sensor was also investigated for DA sensing in real samples like human serum.

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