The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea

Seo, Il Hyeok; Seo, Hyo Jung; Na, Dasom; Yoo, Mooyoung; Schwint, Amanda; Kim, Se Hyun; Lee, Jeongwoo; Jeon, Sang-June; Choi, Jae Won; Kim, Woo Hyoung; Park, Kawngwoo; Yee, Gi-Taek; Kim, Woo-Kyung

doi:10.1016/j.apradiso.2023.110794

상세 보기

The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea

Seo, Il Hyeok;
Seo, Hyo Jung;
Na, Dasom;
Yoo, Mooyoung;
Schwint, Amanda;
... Park, Kawngwoo;
... Yee, Gi-Taek;
... Kim, Woo-Kyung;
외 5명

Citations

WEB OF SCIENCE

2

Citations

SCOPUS

2

초록

A proton linac based boron neutron capture therapy system (A-BNCT, 10MeV, 4mA) was successfully developed in Korea. We performed in vitro experiments with U87 and SAS cells and revealed the efficacy of a binary therapy BNCT using epithermal neutrons and boronophenylalanine (BPA). The results revealed that BNCT showed cancer cell selectivity and caused cell death. Further in vitro studies can be a valuable method to characterize an A-BNCT system. We expect BNCT to become a treatment option for cancer patients.

키워드

TUMOR; LAT1; HEAD

제목: The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea

저자: Seo, Il Hyeok; Seo, Hyo Jung; Na, Dasom; Yoo, Mooyoung; Schwint, Amanda; Kim, Se Hyun; Lee, Jeongwoo; Jeon, Sang-June; Choi, Jae Won; Kim, Woo Hyoung; Park, Kawngwoo; Yee, Gi-Taek; Kim, Woo-Kyung

DOI: 10.1016/j.apradiso.2023.110794

발행일: 2023-07

유형: Article

저널명: Applied Radiation and Isotopes

권: 197

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

ISSN: E 1872-9800
P 0969-8043