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The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development
- Thuy Trang Nguyen;
- Hulme, John;
- Tuong Kha Vo;
- Giau Van Vo
Citations
WEB OF SCIENCE
19Citations
SCOPUS
20초록
The bidirectional communication between the brain and peripheral organs have been widely documented, but the impact of visceral adipose tissue (VAT) dysfunction and its relation to structural and functional brain changes have yet to be fully elucidated. This review initially examines the clinical evidence supporting associations between the brain and VAT before visiting the roles of the autonomic nervous system, fat and glucose metabolism, neuroinflammation, and metabolites. Finally, the possible effects and potential mechanisms of the brain-VAT axis on the pathogenesis of Alzheimer's disease are discussed, providing new insights regarding future prevention and therapeutic strategies.
키워드
Alzheimer's disease; VAT; Crosstalk; Brain; Visceral adipose tissue; WHITE-MATTER LESIONS; BODY-MASS INDEX; T-REG CELLS; LIPID-PEROXIDATION; INSULIN-RESISTANCE; FAT ACCUMULATION; DISEASE; AGE; OBESE; INFLAMMATION
- 제목
- The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development
- 저자
- Thuy Trang Nguyen; Hulme, John; Tuong Kha Vo; Giau Van Vo
- 발행일
- 2022-06
- 유형
- Review
- 권
- 47
- 호
- 6
- 페이지
- 1503 ~ 1512
- 언어
- ENG
- 출판사
- SPRINGER/PLENUM PUBLISHERS
- 발행국가
- 미국
- 분량
- 10 페이지
- ISSN
- E 1573-6903
P 0364-3190