Chemical constituents of Impatiens balsamina stems and their biological activities

Kim, D.H.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R.

doi:10.20307/nps.2019.25.2.130

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Chemical constituents of Impatiens balsamina stems and their biological activities

Kim, D.H.;
Lee, T.H.;
Subedi, L.;
Kim, S.Y.;
Lee, K.R.

Citations

SCOPUS

12

초록

The purification of the MeOH extract from Impatiens basamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2-12). The structure of the new compound (1) was determined by spectral data analysis (1H and13C-NMR,1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1-12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 µM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively. © 2019, Korean Society of Pharmacognosy. All rights reserved.

키워드

Balsaminaceae; Impatiens balsamina; Neuroprotective effect; Tetrahydronaphthalene; 1 beta 2 alpha 4 beta triol 1,2,3,4 tetrahydronaphthalene; 1 beta 2 beta 4 beta triol 1,2,3,4 tetrahydronaphthalene; 29 nor 20 oxolupeol; 4 hydroxybenzoic acid; 7r,8s dihydrodehydrodiconiferyl alcohol 9 beta o d glucopyranoside; alpha spinasterol; beta amyrin; erythrodiol; Impatiens balsamina extract; kaempferol 3 o beta d glucopyranoside; lupenone; lupeol; nicotiflorin; nitric oxide; phytochemical; plant extract; plant medicinal product; unclassified drug; animal cell; Article; biological activity; C6 cell line (glioma); carbon nuclear magnetic resonance; cell viability; chemical composition; chemical structure; controlled study; cytotoxicity; drug synthesis; electrospray mass spectrometry; enzyme linked immunosorbent assay; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; high performance liquid chromatography; human; human cell; IC50; Impatiens; mass fragmentography; mouse; MTT assay; nonhuman; phytochemistry; plant stem; proton nuclear magnetic resonance; thin layer chromatography; upregulation

제목: Chemical constituents of Impatiens balsamina stems and their biological activities

저자: Kim, D.H.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R.

DOI: 10.20307/nps.2019.25.2.130

발행일: 2019-06

유형: Article

저널명: Natural Product Sciences

권: 25

호: 2

페이지: 130 ~ 135