MXene-integrated Cu-Sn bimetallic hydroxide for electrochemical detection of epinephrine

초록

Accurate determination of epinephrine (EN) is crucial for the early diagnosis and monitoring of neurodegenerative disorders. In this study, a novel electrochemical sensor was developed by integrating copper-tin-based bimetallic hydroxide (CuSnOH) with MXene (Mx) to enhance sensing performance. The structural, morphological, and chemical properties of the synthesized CuSnOH@Mx nanocomposites were systematically characterized. Scanning electron microscopy and transmission electron microscopy revealed the surface morphology, while X-ray diffraction confirmed the crystalline structure. Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy were employed to identify the functional groups and analyze the valence states of the constituent elements. A glassy carbon electrode was subsequently modified with the CuSnOH@Mx composite to fabricate a high-performance electrochemical sensor. The modified electrode demonstrated significantly improved electrochemical properties, including low charge transfer resistance (95 Omega), increased electroactive surface area (0.12 cm2), and enhanced electron transfer kinetics (4.6 & times; 10-4 cm s- 1). Owing to these favorable characteristics, the sensor exhibited excellent analytical performance for EN detection, with high sensitivity, remarkable selectivity, and a low limit of detection of 0.14 mu M. Overall, the developed CuSnOH@Mx/GCE sensor demonstrates reliable and efficient EN detection, highlighting its potential for future neurochemical diagnostic research.

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