Effect of Calcination Temperatures on Crystallite Size, Particle Size, and Antimicrobial Activity of Synthesized MgO and Its Cytotoxicity

초록

The development of antimicrobial agents with excellent antimicrobial activity, high thermal stability, and non-toxic properties is an essential demand in food packaging, pharmaceutical, and biomedical applications. In the present study, MgO nanoflakes were synthesized via the co-precipitation method by varying calcination temperatures at 400, 500, and 600 degrees C. The effect of calcination temperature on the morphology, thermal stability, antimicrobial activity, and cytotoxicity of the MgO nanoflakes was analyzed. All synthesized MgO samples showed a Face-Centered Cubic (FCC) structure. As the calcination temperature increased, the MgO crystallite and particle sizes increased, whereas the surface area decreased. In addition, the MgO synthesized from higher calcination temperatures showed higher thermal stability and crystallinity. The MgO synthesized from the lower calcination temperatures (400 and 500 degrees C) showed superior antimicrobial activity against Escherichia coli (100% R) and Staphylococcus aureus (100% R) than that from the higher calcination temperature (600 degrees C). The cytotoxicity test demonstrates slight cytotoxicity in MgO-400 degrees C at concentrations ranging from 100 to 200 mu g/mL. Interestingly, MgO-500 degrees C and MgO-600 degrees C demonstrate biocompatibility and exhibit non-cytotoxic effects, respectively, highlighting their potential for practical applications in active food packaging and biomedical fields.

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