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gamma-Functionalization of alpha,beta-Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4-Aryl-2-Bromopyridines
- Sim, Jaeuk;
- Viji, Mayavan;
- Rhee, Jeongtae;
- Jo, Hyeju;
- Cho, Suk Joon;
- ... Seo, Seung-Yong;
- 외 4명
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18초록
The front cover picture, designed by Jaeuk Sim from the group of Heesoon Lee and Jae-Kyung Jung, illustrates the synthesis of 4-aryl-2-halopyridines via gamma-functionalization of alpha,beta-unsaturated nitriles. Our method features enamine formation at the gamma-position of vinylogous nitriles followed by cyclization to heteroaromatics. In commemoration of Christmas, this picture depicts the reagents gathered around the Christmas tree to create diverse heterocycles through the enamine intermediates. Details of this work can be found in the Update on pages xxxx-xxxx (J. Sim, M. Viji, J. Rhee, H. Jo, S. J. Cho, Y. Park, S.-Y. Seo, K.-Y. Jung, H. Lee, J.-K. Jung, Adv. Synth. Catal. 2019, 361, xxxx-xxxx; DOI: 10.1002/adsc.201901002).
키워드
- 제목
- gamma-Functionalization of alpha,beta-Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4-Aryl-2-Bromopyridines
- 저자
- Sim, Jaeuk; Viji, Mayavan; Rhee, Jeongtae; Jo, Hyeju; Cho, Suk Joon; Park, Yunjeong; Seo, Seung-Yong; Jung, Kwan-Young; Lee, Heesoon; Jung, Jae-Kyung
- 발행일
- 2019-12-03
- 유형
- Article
- 권
- 361
- 호
- 23
- 페이지
- 5458 ~ 5465