Differential Effects of Western and High-fat Diets on the Acceleration of Psoriatic Inflammation

초록

Diet-induced metabolic changes can aggravate psoriatic inflammation. This studyinvestigated the distinct inflammatory effects induced by a high-fat diet (HFD)and Western diet (WD) in mice by inducing psoriatic inflammation using topicalimiquimod following 12 weeks on either diet. Both diets resulted in increasedbody weight and perigonadal fat mass compared to a chow diet, with HFD-fedmice gaining more weight. Fasting glucose levels were significantly elevated onlyin the HFD group. During psoriatic inflammation, WD-fed mice exhibited morepronounced weight loss and aggravated clinical signs of psoriasis. Systemicinflammatory responses, indicated by spleen weight and soluble CD14 serumlevels, were increased in both HFD- and WD-fed mice compared to the chow-fedgroup, with no significant difference between the two diet groups. However,localized inflammatory responses in skin lesions were more pronounced in WDfedmice, with increased expression of inflammatory mediators. The intestinal immuneenvironment and microbiome composition showed no significant differencesbetween the diet groups. Transcriptomic analysis of skin lesions identified differentiallyexpressed genes, with WD-fed mice enriched in gene sets related toinflammation, keratinization, and cornified envelope formation. In contrast, HFD-fedmice were enriched in genes related to tissue microenvironment remodeling. These findings suggest that WD exacerbates psoriatic skin inflammation morethan HFD by promoting inflammatory responses in the skin, highlighting dietspecificimpacts on localized inflammation.

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