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Antiobesity effects of melanin-concentrating hormone receptor 1 (MCH-R1) antagonists
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SCOPUS
17초록
Despite remarkable progress in the elucidation of energy balance and regulation, the development of new antiobesity drugs is still at the stage of infancy. This review describes the MCH and MCH receptor system with regard to its involvement in energy homeostasis and summarizes the pharmacological profiles of selected small molecule MCH-R1 antagonists that are relevant for their development as antiobesity drugs. Although their clinical value still has to be demonstrated, and challenges with regard to unwanted side effects remain to be resolved, MCH-R1 antagonists may provide an effective pharmacotherapy for the treatment of obesity in the near future. © 2012 Springer-Verlag Berlin Heidelberg.
키워드
Energy expenditure; Energy intake; Melanin-concentrating hormone; Obesity; Pharmacotherapy; a 761; a 777903; alb 127158; amg 075; amg 076; amgn 608450; antiobesity agent; atc 0175; daba 821; gw 803430; gw 856464; melanin concentrating hormone receptor; melanin concentrating hormone receptor 1; melanin concentrating hormone receptor 1 antagonist; n (6 dimethylaminomethyl 5,6,7,8 tetrahydro 2 naphthyl) 4' fluoro 1,1' biphenyl 4 carboxamide; nbi 845; ngd 4715; rimonabant; sb 568849; snap 7941; snap 94847; t 0910792; unclassified drug; unindexed drug; us 2005137243; wo 2003047568; wo 2003106452; wo 2004092181; wo 2005034947; wo 2005103039; wo 2007012670; antiobesity agent; MCHR1 protein, human; somatostatin receptor; antiobesity activity; anxiety disorder; depression; dose response; drug activity; drug bioavailability; drug blood level; drug brain level; drug distribution; drug effect; drug efficacy; drug half life; drug mechanism; drug penetration; drug potency; drug protein binding; drug safety; drug screening; drug structure; drug synthesis; drug tolerability; homeostasis; human; low drug dose; maximum plasma concentration; nonhuman; obesity; priority journal; review; animal; drug antagonism; energy metabolism; food intake; metabolism; obesity; pathophysiology; psychological aspect; weight reduction; Animals; Anti-Obesity Agents; Appetite Regulation; Energy Metabolism; Homeostasis; Humans; Obesity; Receptors, Somatostatin; Weight Loss
- 제목
- Antiobesity effects of melanin-concentrating hormone receptor 1 (MCH-R1) antagonists
- 저자
- Cheon, H.G.
- 발행일
- 2012-01
- 유형
- Review
- 권
- 209
- 페이지
- 383 ~ 403
- 언어
- ENG
- 출판사
- Springer Nature
- 발행국가
- 독일
- 분량
- 21 페이지
- ISSN
- P 0171-2004