갈근 추출물이 에스트로겐 결핍 Rat의 비만관련 호르몬에 미치는 영향

초록

Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract onobesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats asestrogen-deficient obesity rat model. They were grouped Normal (sham operation group),Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL(ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels ofhormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin wereestimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin inestrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradioland CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin inestrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormonesrelated to energy metabolism. PL extract decreased the serum levels of leptin. PL extractincreased the serum levels of estradiol and CCK. These results indicate that PL might havepotentials for treatment of obesity and complications during the menopause caused byestrogen-deficiency. Key Words: Obesity, Pueraria

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