Screening of Vietnamese herbal medicines with inhibitory effect on aldose reductase (XI)

Choi, S.-J.; Kim, Y.S.; Kim, J.H.; Kim, J.S.

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Screening of Vietnamese herbal medicines with inhibitory effect on aldose reductase (XI)

베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI)

Choi, S.-J.;
Kim, Y.S.;
Kim, J.H.;
Kim, J.S.

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초록

Aldose reductase (AR) has been indicated the critical enzyme of the polyol pathway in the development of the diabetic complications. In this study, 119 Vietnamese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Synedrella nodiflora (stems and leaves), Combretum sundaicum (stems and leaves), Argyreia acuta (stems and leaves), Platea latifolia (whole plants), Linociera sangda (whole plants), Rhaphiolepis indica (whole plants), Harrisonia perforata (stems and leaves) and 2 fractions from Harrisonia perforata (stems and leaves) with EtOAc and BuOH, exhibited a significant inhibitory activity against AR. Particularly, S. nodiflora, A. acuta and H. perforata (stems and leaves) showed 1.0-1.8 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG). © 2015, Korean Society of Pharmacognosy. All rights reserved.

키워드

Aldose reductase inhibitor; Diabetic complications; Vietnamese herbal medicines; aldehyde reductase; tetramethyleneglutaric acid; Argyreia acuta; Article; Combretum sundaicum; controlled study; drug screening; Harrisonia perforata; herbal medicine; Linociera sangda; nonhuman; plant; plant leaf; plant stem; Platea latifolia; Rhaphiolepis indica; Synedrella nodiflora; Vietnamese

제목: Screening of Vietnamese herbal medicines with inhibitory effect on aldose reductase (XI)

제목 (타언어): 베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI)

저자: Choi, S.-J.; Kim, Y.S.; Kim, J.H.; Kim, J.S.

발행일: 2014-12

유형: Article

저널명: 생약학회지

권: 45

호: 4

페이지: 366 ~ 375

언어: KOR

출판사: Korean Society of Pharmacognosy

발행국가: 대한민국

분량: 10 페이지

ISSN: P 0253-3073