Revealing the clinical potential of high-resolution organoids

  • Ko, Jihoon; 
  • Hyung, Sujin; 
  • Cheong, Sunghun; 
  • Chung, Yoojin; 
  • Jeon, Noo Li
Citations

WEB OF SCIENCE

14
Citations

SCOPUS

17

초록

The symbiotic interplay of organoid technology and advanced imaging strategies yields innovative breakthroughs in research and clinical applications. Organoids, intricate three-dimensional cell cultures derived from pluripotent or adult stem/progenitor cells, have emerged as potent tools for in vitro modeling, reflecting in vivo organs and advancing our grasp of tissue physiology and disease. Concurrently, advanced imaging technologies such as confocal, light -sheet, and two -photon microscopy ignite fresh explorations, uncovering rich organoid information. Combined with advanced imaging technologies and the power of artificial intelligence, organoids provide new insights that bridge experimental models and real -world clinical scenarios. This review explores exemplary research that embodies this technological synergy and how organoids reshape personalized medicine and therapeutics.

키워드

HUMAN BRAIN ORGANOIDS; HUMAN IPS CELLS; STEM-CELL; INTESTINAL ORGANOIDS; RETINAL ORGANOIDS; IN-VITRO; HEPATOCELLULAR-CARCINOMA; PHENOTYPIC LANDSCAPE; SELF-ORGANIZATION; NEURAL RETINA
제목
Revealing the clinical potential of high-resolution organoids
저자
Ko, Jihoon; Hyung, Sujin; Cheong, Sunghun; Chung, Yoojin; Jeon, Noo Li
DOI
10.1016/j.addr.2024.115202
발행일
2024-04
유형
Review
저널명
Advanced Drug Delivery Reviews
권
207