Separacene E, a New Tetraene Polyketide from the Marine Actinomycete, Streptomyces sp. SNJ210

초록

– The One Strain MAny Compounds (OSMAC) strategy resulted in discovery of a new tetraene mono-ol, separacene E (1), a new derivative of previously reported separacenes A-D from Streptomyces sp. SNJ210. The chemical structure of 1 was determined by NMR, mass, UV spectroscopy, and specific rotation calculations. Separacene E (1) possesses a methylated tetraene moiety along with a terminal carboxyl group, whereas separacenes A–D bear polyene polyol substructures. Separacene E (1) displayed moderate cytotoxicity against cancer cell line. © 2025, Korean Society of Pharmacognosy. All rights reserved.

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