Lonicera caerulea: An updated account of its phytoconstituents and health-promoting activities

초록

Background: Blue honeysuckle (Lonicera caerulea) is a perennial plant of the Caprifoliaceae family that has captured considerable attention in recent years as a health functional food. Many distinct and unique phytoconstituents have been introduced alongside bioactivities, mounting the nutritional and biological uses of this plant as a functional food and in traditional medicine. Scope and approach: The paper covers comprehensive information on the nutritional and phytochemical components of honeysuckle, including phenolic acids, flavonoids, organic acids, triterpenoids, iridoids, and fatty acids. Meanwhile, bioactivities that promote health, including antioxidant, anti-obesity, anti-inflammatory, anti-diabetic, cardio protective, antitumor, liver and lung protective, and antimicrobial activities based on in vitro and in vivo studies, have also been included. The review briefly summarizes a few published and unpublished human studies. In addition, it also outlines commercial applications and future perspectives and challenges. Key Findings and Conclusions: About 186 chemicals have been identified from different parts of the honeysuckle. Its newly identified compounds are triterpenoids, iridoids, and fatty acids. Overall, the plant has many pharmacological activities, as confirmed by in vitro and in vivo studies. Since significant clinical data on blue honeysuckle are scarce, well-designed human intervention studies are required to further confirm the biological activity in humans. © 2020 Elsevier Ltd

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