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Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney
- Lee, Ji Hwan;
- Park, Musun;
- Jung, Kiwon;
- Hong, Gyeongmin;
- Lee, Hye Lim;
- ... Kim, Chang-Eop;
- ... Kang, Ki Sung;
- 외 1명
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9초록
Tacrolimus (FK506), a calcineurin inhibitor, is an effective immunosuppressive agent mainly used to lower the risk of organ rejection after allogeneic organ transplant. However, FK506-associated adverse effects, such as nephrotoxicity, may limit its therapeutic use. In this study, we confirmed that epigallocatechin-3-gallate (EGCG), sanguiin H-6, and gallic acid increased cell survival following FK506-induced cytotoxicity in renal epithelial LLC-PK1. Among these compounds, gallic acid exerted the strongest protective effect, further confirmed in the FK506-induced nephrotoxicity rat model. Additionally, we identified supporting evidence for the nephroprotective function of gallic acid using molecular docking and bioavailability investigations. © 2021 Elsevier Ltd
키워드
- 제목
- Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney
- 저자
- Lee, Ji Hwan; Park, Musun; Jung, Kiwon; Hong, Gyeongmin; Lee, Hye Lim; Kim, Dong-Wook; Kim, Chang-Eop; Kang, Ki Sung
- 발행일
- 2021-06-01
- 유형
- Article
- 권
- 41