Emerging trends, and prospects in Nanozyme engineering to enhance dual-mode sensing applications

초록

Increasing necessity towards the advancement of detection systems has sparked considerable curiosity in integrated dual-modal sensing technologies. The recent progress in the fields of nanozymes and materials chemistry highlights the significance of integrated dual-mode systems for biomedical sensing applications. Interestingly, the combination of two detection signals can enhance diagnostic performance, while minimizing assumptions. Moreover, the integrated technologies boost diagnostic capabilities through immense flexibility, improved accuracy, and broad-range detection. In this perspective, nanozymes have been incorporated into a variety of dual-mode biosensing systems due to their enhanced catalytic activities; and they provide benefits of low cost, high stability, ease of surface tuning, and biocompatibility. Herein, dual-mode biosensing, which leads two output signals can be combination of colorimetric, fluorescent, photothermal, electrochemical, or SERS, owing to their remarkable benefits for sensitive and real-time detection as well as the development of point-of-care (POC) devices. In this seminal review, an in-depth fundamental understanding of different nanozymes-based dual-mode sensing techniques i.e. colorimetric/fluorimetric, colorimetric/photothermal, colorimetric/electrochemical, and colorimetric/SERS, has been provided, followed by emphasizing their usage in sensing applications. Here, a comprehensive analysis has also been conducted for the sensing methodologies involving nanozyme-based sensor arrays, synergistic catalytic activities, and the foundational principles of the signal transduction systems, while addressing the challenges and future opportunities for the progress in the domain.

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