Defect-engineered NiFe-LDH/MXene composite: A reliable and ultra-sensitive sensor for nilutamide

초록

The 2D/2D interface engineering approach offers a versatile and high-performance framework for electrochemical sensors that detect a broad spectrum of nitro compounds, paving the way for advancements in nextgeneration sensors and point-of-care technology. Herein, an ultra-sensitive nilutamide (NLT) sensor using defect-rich NiFe-layered double hydroxide/tungsten carbide MXene (d-NiFe-LDH/WC) composite via a 2D/2D interface engineering method, leveraging the synergistic effects of high redox activity and exceptional conductivity. The development of a defect-rich NiFe-LDH/WC nanocomposite was validated by structural and morphological investigations. The electrochemical investigations using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) revealed that NLT could be more precisely detected. The methods had a dual linear detection range of 0.002-5.82 mu M and 5.82-545.34 mu M, with an ultra-low limit of detection (LOD) of 0.7 nM. The sensor exhibited excellent reproducibility, minimal interference from common chemicals and bioactive species, and reliable recoveries ranging from +/- 96.57 % to 99.75 % in spiked real samples, including water, serum, and urine, highlighting its potential for practical applications. To detect trace amounts of NLT in real-world samples, the proposed innovative sensor offers an easy-to-use, highly sensitive electrochemical sensing approach.

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