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카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과
- Sym, Eunjin;
- Shim, Won Sik
초록
Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality oflife. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety andefficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) − an endogenous lipid with a putative antinociceptiveeffect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system,which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselectivecation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentiallysafe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, andthe function of AA-5-HT in pain modulation.
키워드
- 제목
- 카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과
- 제목 (타언어)
- Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1
- 저자
- Sym, Eunjin; Shim, Won Sik
- 발행일
- 2021-08
- 저널명
- 약 학 회 지
- 권
- 65
- 호
- 4
- 페이지
- 237 ~ 245
- 언어
- KOR
- 출판사
- 대한약학회
- 발행국가
- 대한민국
- 분량
- 9 페이지
- ISSN
- P 0377-9556