The Relationship between the Causative Allergens of Allergic Diseases and Environments in Korea Over a 8-Year-Period: Based on Skin Prick Test from 2006 to 2015

초록

Background and Objectives: The present study evaluated the results of skin prick test using 55 allergens at 20 centers inthe Republic of Korea in 2006, 2010, and 2014-2015. The aim was to assess changes in the positive rate of allergens accordingto temporal, regional, and environmental factors. Materials and Method: In total, 20 hospitals were selected based on the population distribution in the Republic of Korea. Askin prick test panel comprising 55 aeroallergens was distributed to 18 hospitals for this prospective study. The 2006 and 2010skin prick test results were collected and analyzed retrospectively from 20 hospitals, while the 2014/2015 skin prick test results(from June 2014 to May 2015) were collected prospectively from 18 hospitals. Results: A total of 14,897 SPT test results were analyzed: 4,319 in 2006, 7,431 in 2010, and 1,852 in 2014/2015. The overallrate of skin prick test positivity to more than two allergens was significantly higher in males than females. The positive rates ofalder pollens and birch, oak and ragweed pollen positivity were increased in older patients. Several positive rates were increased according to the temperature in spring. The positive rates for beech pollen, birch pollen, hazel pollen, oak pollen, Tyrophagusputrescentiae, mugwort, cat, Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae were significantly increased,while those of Cult rye pollen and dandelion were significantly decreased over the three test periods. The overall positive ratefor allergens in Jeju province varied significantly from Seoul and other cities. Conclusion: Change in the positive rate of multiple aeroallergens was evaluated in the Republic of Korea over time. Our findingscan be used to recommend aeroallergens suitable for inclusion in skin prick test panels in the Republic of Korea and willfacilitate further investigation of changes in the patterns of allergic diseases.

키워드