PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp(2))-H or C(sp(3))-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water

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초록

A novel nitration (via C(sp(3))-N breaking/C(sp(2))-N formation with CH3NO2) mediated by [bis-(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp(2))-H functionalization can shift to an alpha-C(sp(3))-H functionalization (cyanation or oxygenation) of the alpha-C(sp(3))-H of cyclic amines.

키워드

HYPERVALENT IODINE REAGENTSAROMATIC NITRATIONTERTIARY-AMINESH FUNCTIONALIZATIONCONJUGATE ADDITIONSODIUM-NITRITEUREA NITRATENITROMETHANEOXIDATIONATOM
제목
PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp(2))-H or C(sp(3))-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water
저자
CHANDRASHEKAR, MUDITHANAPELLIDhorma, Lama PremaKim, Mi-hyun
DOI
10.1021/acs.orglett.9b00751
발행일
2019-05
유형
Article
저널명
Organic Letters
21
9
페이지
3098 ~ 3102