Emerging Trends in Artificial Intelligence-Assisted Colorimetric Biosensors for Pathogen Diagnostics

초록

Infectious diseases caused by bacterial and viral pathogens remain a major global threat, particularly in areas with limited diagnostic resources. Conventional optical techniques are time-consuming, prone to operator errors, and require sophisticated instruments. Colorimetric biosensors, which convert biorecognitive processes into visible color changes, enable simple and low-cost point-of-care testing. Artificial intelligence (AI) enhances decision-making by enabling learning, training, and pattern recognition. Machine learning (ML) and deep learning (DL) improve diagnostic accuracy, but they do not autonomously adapt and are pre-trained on complex color variation, whereas traditional computer-based methods lack analysis ability. This review summarizes major pathogens in terms of their types, toxicity, and infection-related mortality, while highlighting research gaps between conventional optical biosensors and emerging AI-assisted colorimetric approaches. Recent advances in AI models, such as ML and DL algorithms, are discussed with a focus on their applications to clinical samples over the past five years. Finally, we propose a prospective direction for developing robust, explainable, and smartphone-compatible AI-assisted assays to support rapid, accurate, and user-friendly pathogen detection for health and clinical applications. This review provides a comprehensive overview of the AI models available to assist physicians and researchers in selecting the most effective method for pathogen detection.

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