Non-enzymatic electrochemical sensor based on Ti3C2Tx/HEOx nanocomposites for rapid detection of dopamine and acetaminophen towards real-time monitoring in biological fluid

초록

The rapid and sensitive detection of biomolecules such as dopamine (DA) and acetaminophen (ACP) is decisive for real-time monitoring of neurological and pharmacological conditions. In this current study, the Ti3C2Tx/HEOx oxide (Fe Co Cu Ni Ti) nanocomposites were prepared by using a simple hydrothermal method. The as-prepared samples were examined to identify their physiochemical properties. The Ti3C2Tx/HEOx nanocomposite sample was integrated into a glassy carbon electrode (GCE) to form Ti3C2Tx/HEOx/GCE electrode and was used in electrochemical simultaneous detection of DA, a neurotransmitter, and ACP, a pain-relieving drug. The detection limit (LOD), detection range, and sensitivity were measured to be 0.24 mu M (LOD for DA), 0.29 mu M (LOD for ACP), 5-45 mu M and 1.3282 (DA), 0.827 (ACP) mu A mu M-1 cm-2, respectively. Overall, the results, show the good selectivity and antifouling characteristics for dual detection of DA and ACP. The detection of DA and ACP was carried out in real samples such as urine and tablet samples with a good recovery range. Finally, our observations reveal that the developed high-performance sensor enables real-time monitoring of these important biomarkers in biological samples with high specificity and minimal interference from other substances.

키워드