Complexities of Prostate Cancer

Citations

WEB OF SCIENCE

181
Citations

SCOPUS

197

초록

Prostate cancer has a long disease history and a wide variety and uncertainty in individual patients' clinical progress. In recent years, we have seen a revolutionary advance in both prostate cancer patient care and in the research field. The power of deep sequencing has provided cistromic and transcriptomic knowledge of prostate cancer that has not discovered before. Our understanding of prostate cancer biology, from bedside and molecular imaging techniques, has also been greatly advanced. It is important that our current theragnostic schemes, including our diagnostic modalities, therapeutic responses, and the drugs available to target non-AR signaling should be improved. This review article discusses the current progress in the understanding of prostate cancer biology and the recent advances in diagnostic and therapeutic strategies.

키워드

prostate cancer; PSA; resistance; mutation; AR signaling; ANDROGEN RECEPTOR; DNA-REPAIR; GENE FUSIONS; HOMOLOGOUS RECOMBINATION; RADICAL PROSTATECTOMY; ACTIVE SURVEILLANCE; GENOMIC ALTERATIONS; MEMBRANE ANTIGEN; ERG EXPRESSION; FAMILIAL RISK
제목
Complexities of Prostate Cancer
저자
Wasim, Sobia; Lee, Sang-Yoon; Kim, Jaehong
DOI
10.3390/ijms232214257
발행일
2022-11
유형
Review
저널명
International Journal of Molecular Sciences
권
23
호
22