Polymeric biocide-modified zinc oxide@alginate nanocomposites for drug delivery and antibacterial applications

  • Mohan, Anandhu
  • Santhamoorthy, Madhappan
  • Ashwini, Munusamy
  • Mani, Kailasam Saravana
  • Ramkumar, Vanaraj
  • 외 4명
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초록

A polymeric biocide polyhexamethylene guanidine (PHMG) modified alginate-coated zinc oxide nanocomposite (ZnO@Alg-PHMG) has been proposed for drug delivery and antibacterial applications. A range of instrumental characterizations including FT-IR, XRD, SEM, TGA, and zeta potential were utilized to verify the ZnO@AlgPHMG synthesis. The drug delivery behavior of the ZnO@Alg-PHMG was determined using curcumin (Cur) as a model antibacterial agent. Further, the PHMG-induced antibacterial activity of the ZnO@Alg-PHMG was evaluated against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli) bacterial pathogens.

키워드

ZnO nanoparticlesPolymeric biocideDrug deliveryPHMGAntibacterial activityPH
제목
Polymeric biocide-modified zinc oxide@alginate nanocomposites for drug delivery and antibacterial applications
저자
Mohan, AnandhuSanthamoorthy, MadhappanAshwini, MunusamyMani, Kailasam SaravanaRamkumar, VanarajLin, Mei-ChingKim, Seong-CheolKumarasamy, KeerthikaPhan, Thi Tuong Vy
DOI
10.1016/j.matlet.2024.136938
발행일
2024-10
유형
Article
저널명
Materials Letters
372