Selective sensing of dopamine using copper hollow tube-integrated conjugated poly(arylene-ethynylene)-4 in the presence of epinephrine and norepinephrine

초록

The Sonagashira-Hagihara coupling reaction was employed to prepare the conjugated Poly(arylene-ethynylene)-4 (CMP-4), into which copper hollow tubes (Cu-HT) were incorporated. This incorporation significantly enhanced the electrical conductivity and the selectivity of CMP-4 for dopamine (DA). The resulting composite exhibited high selectivity for DA over norepinephrine (NE) and epinephrine (EP) in a PBS-urine electrolyte. The peak current displayed a linear relationship with DA concentrations ranging from 100 to 900 nM, with limits of detection (LODs) of 17.84 and 16.03 nanomolar (R2 = 0.9906). This selective DA sensing is attributed to the adsorption of the analyte on the CMP-Cu-4-GCE surface, facilitated by aromatic functionality, soft–soft interactions, Lewis basicity, and steric hindrance. Additionally, the CMP-Cu-4-GCE demonstrated remarkable sensitivity, stability, selectivity, and reproducibility in DA detection. Voltammetric results from the screen-printed electrode (SPE) using CMP-Cu-4-SPE suggest that it is a promising electrochemical probe for detecting DA in a PBS-urine solvent. © 2024 The Korean Society of Industrial and Engineering Chemistry

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