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Modulation of melanin synthesis by amaranthus spp. L seed extract in melan-a cells
- Seo, J.O.;
- Do, M.H.;
- Lee, J.H.;
- Lee, T.H.;
- Wahedi, H.M.;
- ... Kim, S.Y.;
- 외 1명
SCOPUS
2초록
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food. © 2016, Korean Society of Pharmacognosy. All rights reserved.
키워드
- 제목
- Modulation of melanin synthesis by amaranthus spp. L seed extract in melan-a cells
- 저자
- Seo, J.O.; Do, M.H.; Lee, J.H.; Lee, T.H.; Wahedi, H.M.; Park, Y.U.; Kim, S.Y.
- 발행일
- 2016-09
- 유형
- Article
- 권
- 22
- 호
- 3
- 페이지
- 168 ~ 174