BiFeO3/carbon black-modified screen-printed electrode for sensitive electrochemical determination of furazolidone

초록

Antibiotic resistance is a major concern to the global health, highlighting the need for new techniques for the targeted identification and analysis of specific antibiotic drugs. This study addresses the electrochemical detection of the pharmaceutical agent furazolidone (FZD). A BiFeO3/carbon black-modified screen-printed carbon electrode (BiFeO3/CB@SPCE) was evaluated for the electrochemical determination of furazolidone (FZD). Although BiFeO3/carbon composites have previously been explored for electrochemical sensing, the present study focuses on their application in a disposable SPCE format for FZD-specific cathodic detection. The electrochemical response of FZD was evaluated across a concentration range of 0.01-130 & micro;M and pH range of 3.0-11.0 in phosphate-buffered saline (PBS). Interference studies were conducted using common ions and biomolecules. The fabricated biosensor exhibited high stability, reproducibility, and a low detection limit (LOD) of 0.045 & micro;M. A wide linear response range (0.01-130 & micro;M) was achieved owing to the synergistic effects of the nanocomposite, outperforming comparable BiFeO3/CB-based electrodes reported at 200 & micro;M. The highest cathodic current (-42.59 & micro;A at -0.38 V) was observed at pH 7. The sensor showed excellent selectivity in the presence of Na+, K+, Ca2+, Mg2+, Fe3+, Cu2+, ascorbic acid, citric acid, glucose, and fructose. These results demonstrate good repeatability, anti-interference ability, and these results demonstrate the analytical applicability of the BiFeO3/CB@SPCE for sensitive FZD determination in aqueous, biological, and pharmaceutical samples.

키워드