Biological Properties and Phytochemicals of Multipurpose Tree Plant Hagenia abyssinica

초록

Hagenia abyssinica (HA) is a monotypic tree species used as traditional medicine against various diseases and conditions in African countries. HA is also a multipurpose plant used for furniture, fuel wood, soil fertility management, and rainwater conservation, along with medicinal usage. In different in vitro, in vivo, ex vivo, and human studies, the potential of HA for different pharmacological properties, including anti-parasite, antibacterial, antifungal, antispasmodic, anticancer, anti-diabetes, antidiarrheal, wound healing, antioxidant, and anti-inflammatory activities were observed. Antioxidant and anti-inflammation properties of HA may be the primary reason for the multi-pharmacological activities of HA. Initial toxicity studies and the presence of various phytochemicals, especially flavonoids, also support the therapeutic potential of HA. The diverse medicinal properties of the plant have different challenges to overcome for its development. Limited studies to decipher the molecular mechanism behind the pharmacological activity restrict the utilization of the complete potential of HA as therapeutics. Still, the compilation of phytochemical, pharmacological activities, and target pathways of HA is missing in the literature. The current review not only compiles the pharmacological activities and phytochemicals but also highlights the gaps and proposes the future direction to develop HA as a candidate against important diseases.

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