Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers

Park, S. Y.; Lee, J. S.; Son, J. S.; Ko, J. H.; Peck, K. R.; Jung, Y.; Woo, H. J.; Joo, Y. S.; Eom, J. S.; Shi, H.

doi:10.1016/j.jhin.2018.09.005

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Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers

Park, S. Y.;
Lee, J. S.;
Son, J. S.;
Ko, J. H.;
Peck, K. R.;
... Eom, J. S.;
... Shi, H.;
외 3명

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초록

An effective post-exposure prophylaxis (PEP) strategy may limit the spread of infection. However, there is no consensus regarding PEP for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. This study assessed the efficacy of ribavirin and lopinavir/ritonavir as PEP for healthcare workers (HCWs) exposed to patients with severe MERS-CoV pre-isolation pneumonia. The safety of the PEP regimen was assessed. HCWs with high-risk exposure to MERS-CoV pre-isolation pneumonia were retrospectively enrolled. HCWs who received PEP therapy were classified into the PEP group. PEP therapy was associated with a 40% decrease in the risk of infection. There were no severe adverse events during PEP therapy. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

키워드

Post-exposure prophylaxis; Middle East respiratory syndrome coronavirus; Outbreak; Healthcare worker; High-risk exposure; Pre-isolation pneumonia; SYNDROME CORONAVIRUS INFECTION

제목: Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers

저자: Park, S. Y.; Lee, J. S.; Son, J. S.; Ko, J. H.; Peck, K. R.; Jung, Y.; Woo, H. J.; Joo, Y. S.; Eom, J. S.; Shi, H.

DOI: 10.1016/j.jhin.2018.09.005

발행일: 2019-01

유형: Article

저널명: Journal of Hospital Infection

권: 101

호: 1

페이지: 42 ~ 46