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A Rare Combination of CYP2C9*3/*3 and VKORC1 1639AA in a Patient Who Had Myxoma and Thromboembolism
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We report a case of intolerance to warfarin. A 20-year-old woman with toe pain was diagnosed with myxoma with multiple systemic embolisms. She was prescribed warfarin for remaining embolic pain after myxoma excision and mitral annuloplasty. Even on 1 mg of warfarin, the international normalized ratio was much increased. The patient was found to have cytochrome P450 2C9 (CYP2C9)*3/*3 and vitamin K epoxide reductase complex subunit 1 (VKORC1) 1639AA genotype, which is extremely rare in Koreans. Based on this result, we assessed the potential risks and benefits of warfarin and decided to switch to aspirin because the risk of bleeding was considered to be too high. © 2020 The Society of Thoracic Surgeons
키워드
cytochrome P450 2C9; enoxaparin; nonsteroid antiinflammatory agent; warfarin; adult; Article; cancer surgery; case report; clinical article; computer assisted tomography; female; femoral artery; follow up; gene; genotype; heart atrium myxoma; human; international normalized ratio; mitral annuloplasty; pharmacogenetic testing; priority journal; thromboembolism; transthoracic echocardiography; vitamin k epoxide reductase complex subunit 1 gene; World Health Organization; young adult
- 제목
- A Rare Combination of CYP2C9*3/*3 and VKORC1 1639AA in a Patient Who Had Myxoma and Thromboembolism
- 저자
- Son K.H.; Lee S.I.; Choi C.H.; Park K.Y.; Park C.H.
- 발행일
- 2020-04
- 유형
- Article
- 권
- 109
- 호
- 4
- 페이지
- e283 ~ e284