Association of Arterial Stiffness and Osteoporosis in Healthy Men Undergoing Screening Medical Examination

초록

Background: Association of arterial stiffness and osteoporosis has been previously re-ported in women. However, this association is still controversial for men. Therefore, weinvestigated correlation of arterial stiffness and osteoporosis by measuring brachial-an-kle (ba) pulse wave velocity (PWV) and bone mineral density (BMD). Methods: We re-viewed medical charts of 239 people (women: 128, men: 111) who visited the HealthPromotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray ab-sorptiometry. Metabolic syndrome was based on the National Cholesterol EducationProgram (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25kg/m2 was used instead of waist circumference. Results: In Pearson's correlation analy-sis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, to-tal) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and wom-en (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMDand PWV had an independent relationship in women after adjusting for age, metabolicsyndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independentassociation was found between PWV and BMD in men. Conclusions: The association be-tween arterial stiffness and BMD was confirmed in women. However, this associationwas not statistically significant for men.

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